IMPACT
Explore our research
Latest publications
Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1
Restuadi, R., Steyn, F.J., Kabashi, E. et al. Genome Med 14, 7 (2022). https://doi.org/10.1186/s13073-021-01006-6
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
van Rheenen, W., van der Spek, R.A.A., Bakker, M.K. et al. Nat Genet 53, 1636–1648 (2021). https://doi.org/10.1038/s41588-021-00973-1
Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia.
Restuadi, R., Garton, F.C., Benyamin, B. et al. Eur J Hum Genet 30, 532–539 (2022). https://doi.org/10.1038/s41431-021-00885-y
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
Nabais, M.F., Laws, S.M., Lin, T. et al. Genome Biol 22, 90 (2021). https://doi.org/10.1186/s13059-021-02275-5
Latest news
Introducing Dr. Allan McRae to the SALSA-SGC team
Allan leads the Systems Genomics group at IMB and has had a leading role in the analysis of the genomic data generated from the SALSA-SGC collection. He has recently been funded to extend the 'omits data with the inclusion of neurological protein measures in plasma.
Development of a SNP bead chip with custom neurodegenerative content
Work has been undertaken with Illumina over the last 12 months to develop a SNP bead chip that will expand our capacity to screen for mutations associated with MND. The first batch of chips were received early 2022.