Enabling all Australians with MND to contribute to a big-data research resource that integrates clinical, lifestyle and biological information.
FEATURED RESEARCH PROJECT
Using human serum and plasma to determine novel biomarkers for neurodegenerative diseases
Taking results from animal models, this project will screen blood lipids found to be markers of disease progression. Serum and plasma samples accessed from SALSA-SGC will be used for targeted screening of blood lipids knowing that lipid metabolism plays a crucial role in MND. This research will be conducted at the Florey Institute in Melbourne, Victoria, and results are expected late 2022.
Interested in finding out more about this study? Please contact Sophia Luikinga: firstname.lastname@example.org
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
van Rheenen, W., van der Spek, R.A.A., Bakker, M.K. et al. Nat Genet 53, 1636–1648 (2021). https://doi.org/10.1038/s41588-021-00973-1
Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia.
Restuadi, R., Garton, F.C., Benyamin, B. et al. Eur J Hum Genet 30, 532–539 (2022). https://doi.org/10.1038/s41431-021-00885-y
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
Nabais, M.F., Laws, S.M., Lin, T. et al. Genome Biol 22, 90 (2021). https://doi.org/10.1186/s13059-021-02275-5
Genome-wide Meta-analysis Finds the ACSL5-ZDHHC6 Locus is Associated with ALS and Links Weight Loss to the Disease Genetics.
Iacoangeli, A., Lin, T., Al Khleifat, A., et al. (2020). Cell reports, 33(4), 108323. https://doi.org/10.1016/j.celrep.2020.108323
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